Mechanisms of how PRP works

“Proponents of platelet-rich plasma (PRP) technology suggest that its benefits include an increase in hard- and soft-tissue wound healing. In addition, the role of PRP for the treatment of alopecia (areata and androgenic) has been demonstrated in recent reports. The activation of platelet α−granules releases numerous growth factors, including transforming growth factor (TGF), platelet-derived growth factor (PDGF),vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor, and interleukin-1. It is proposed that growth factors released from platelets may act on stem cells in the bulge area of the follicles, stimulating the development of new follicles and promoting neovascularization. In fact, in the bulge area, primitive stem cells of ectodermal origin are found, giving origin to epidermal cells and sebaceous glands. In matrix, germinative cells of mesenchymal origin are found at the dermal papilla. Interactions between these two kinds of cells as well as with binding growth factors (PDGF (platelet-derived growth factor), TGF-β, and VEGF) activate the proliferative phase of the hair, giving rise to the future follicular unit.” [Accessed 7/26/2017]